By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)
P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure sooner than the fifth 12 months and, usually, for instance in breast carcinoma, they relapse nonetheless later as much as the twentieth yr. For a few substantial time, the method of melanoma therapy has been restricted to the sophistication of surgery-radiotherapy mixtures that maximally reduced the prevalence of neighborhood and neighborhood relapses in websites that have been inside of their succeed in. this present day, the perform of medical oncology is unthinkable with no the lively participation of the scientific oncologist. he's the "third guy" of the medical oncology crew, and he has lately centred cognizance at the incontrovertible fact that such a lot relapses come up from far away metastases end result of the proliferation of cells seeded there after having left the first tumor website on the time of operation and, for that reason, are inaccessible to any shape oflocal and/or neighborhood remedy. in this proof, clinical oncologists have proposed the applying of clinical remedies for disseminated minimum residual affliction (MRD). they've got on hand potential: chemother apy and immunotherapy. scientific oncologists more often than not should be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias resembling Hodgkin's sickness, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, inspiration they may have the technique of attacking the residual disorder of universal cancers.
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Extra resources for Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies
DIDIER JACQUMIN'S thesis. References 1. Abelev, G. , Perova, S. , Khramkova, N. , Postnikova, Z. , Irlin, I. : Production of embryonal a globulin by transplantable mouse hepatomas. Transplantation 1, 174-176 (1963) 2. Bergstrand, G. : Demonstration of new protein fraction in serum from human fetus. Scand. J. Clin. Lab. Invest. 8, 174-177 (1956) 3. : Les antigenes de tumeurs et leur detection dans Ie serum: interet des methodes radioimmunologiques. In: Radioimmunoassay and related procedures in medicine.
68. , Salmon, S. E. ), pp. 98-104. Berlin, Heidelberg, New York: Springer 1979 Kinetics of Minimal Residual Disease 15 10. Schabel, F. M. ): Experimental basis for adjuvant chemotherapy. In: Adjuvant therapy of cancer. , Jones, S. ), pp. 3-15. Elsevier, North-Holland 1977 11. : Transplantation of human tumors in nude mice. J. Natl. Cancer Inst. 56, 1251 (1976) 12. : Effects of surgery on the cell kinetics of residual tumor. Cancer Treat. Rep. 60, 1749 (1976) 13. , Schabel, F. ): Quantitative and cytokinetics studies in experimental tumor systems.
One sample every 5-7 days in the post-surgery month; 38 D. Buffe and C. Rimbaut 3. one sample monthly during the lst year; 4. one sample every 3 months during the 2nd year; 5. one sample every 6 months for the next 4 years. Every sample should be tested with the same radioimmunoassay along with the original frozen and retained sample. An increase in the aFP level, even small, could be important. It should be quickly verified and clinical and surgical examinations must be performed to fmd its cause.
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)